Different types of aerobic exercise can cause different disorders of homeostasis. This cross-over experiment aimed to determine the muscle fatigue and the antioxidative protection of female basketball players following a load caused by three different aerobic-type exercises (low-intensity continuous, high-intensity continuous, and high-intensity interval training). Twelve female basketball players (age 17.7±4.3 years; weight 67.3±9.8 kg; height 178.0±7.4 cm) voluntarily participated in the study. A wash-out period of 7 days between single sessions of different training was provided. Venous blood was drawn right before and immediately after each exercise session. The parameters that were analyzed are markers of muscle damage and enzymes of antioxidant protection. As a marker of muscle damage, myoglobin (F=2.884; p=0.065) and lactates (F=5.254; p=0.008) have higher values and statistically significant differences between training types. Creatinine shows higher values after each training session (F=4.053; p=0.022). Results of enzyme activity for oxidative protection show statistically significant differences between groups for catalase (F=5.811; p=0.005) with different types of training intervention. At the beginning of the preparatory period, parameters of acute muscle damage values are high. During the season, in response to different types of training, those parameters decrease in response to the body's adaptation to exercise-induced stress. Training leads to maintenance of physiological balance in the body and oxidative stress is not a necessary phenomenon of high aerobic training load. The inclusion of antioxidant protection enzymes decreases as the body adapts to a certain type of exercise.