THE INFLUENCE OF TOTAL PHYSICAL INACTIVITY ON PLASMA HOMOCYSTEINE LEVELS. RISK FACTOR FOR DEVELOPMENT OF CARDIOVASCULAR DISEASE

Mihaela Jurdana ,
Mihaela Jurdana

College of Health Care Izola, University of Primorska, Koper, Slovenia

Nadja Plazar ,
Nadja Plazar

College of Health Care Izola, University of Primorska, Koper, Slovenia

Rado Pišot
Rado Pišot

Insitute of Kinesiology research, Science and research centre Koper, University of Primorska, Koper, Slovenia

Published: 01.06.2009.

Volume 1, Issue 1 (2009)

pp. 28-32;

https://doi.org/10.31382/EQOL200901089J

Abstract

Physical inactivity is the second most significant risk factor for chronic non-infectious contagious diseases in developed countries. However, conditions have slightly improved in the past few years; still, only 20 % of the population is being active in a fashion to reduce the probability of cardiovascular complications. Epidemiological research has confirmed that regular physical activity and nutrition containing sufficient quantities of folic acid, vitamins B6 and B12, reduce the level of homocysteine in blood. In our research, we studied the influence of long-lasting inactivity on the level of homocysteine and folic acid levels in blood. Ten male subjects were resting in horizontal position for 35 days in a clinical setting. After 35 days of resting we documented a statistically relevant increase in homocysteine level and decrease of folic acid concentration, despite supervised nutrition. We can conclude that prolonged physical inactivity is an autonomous, independent risk factor for the development of cardiovascular diseases. 

Keywords

References

1.
Biolo G, Ciocchi B, Stulle M, Piccoli A, Lorenzon S, Dal Mas V, et al. Metabolic consequence of physical inactivity. Vol. 15, Journal of Renal Nutrition. p. 49–53.
2.
Nygard O, Vollset SE, Refsum H, Stensvold I, Tverdal A, Nordrehaug JE, et al. Total plasma homocysteine and cardiovascular risk profile: The Hordaland Homocysteine Study. Vol. 274, JAMA. p. 1526–33.
3.
Shai I, Stampfer MJ, Ma J, Manson JE, Hankinson SE, Cannuscio C, et al. Homocysteine as a risk factor for coronary heart disease and its association with inflammatory biomarkers, lipids, and dietary factors. Vol. 177, Atherosclerosis. p. 375–81.
4.
Stegnar M. Hiperhomocisteinemija in žilna bolezen. Vol. vestnik, Farmacevtski. p. 343–6.
5.
Guldener C, Stehouwer CDA. Homocysteine metabolism in renal disease. Vol. 41, Clinical Chemistry and Laboratory Medicine. p. 1412–7.
6.
Boden-Albala B, Sacco RL. Lifestyle factors and stroke risk: Exercise, alcohol, diet, obesity, smoking, drug use, and stress. Vol. 2, Current Atherosclerosis Reports. p. 160–6.
7.
Siri PW, Verhoef P, Kok FJ. Vitamins B6, B12, and folate: Association with plasma total homocysteine and risk for coronary atherosclerosis. Vol. 17, Journal of the American College of Nutrition. p. 435–41.
8.
Kraševec-Ravnik E, Bevc-Stankovič M. Svetovni dan gibanja 2008: Telesna dejavnost za vse.
9.
Gaume V, Mougin F, Figard H, Simon-Rigaud ML, N’Guyen UN, Callier J, et al. Physical training decreases total plasma homocysteine and cysteine in middle-aged subjects. Vol. 49, Annals of Nutrition and Metabolism. p. 125–31.
10.
Dankner R, Chetrit A, Dror GK. Physical activity is inversely associated with total homocysteine levels, independent of C677T MTHFR genotype and plasma B vitamins. Vol. 29, Age. p. 219–27.
11.
Clarke R, Levington S, Donald A, Johnston C, Refsum H, Stratton I, et al. Underestimation of the importance of homocysteine as a risk factor for cardiovascular disease in epidemiological studies. Vol. 8, Journal of Cardiovascular Risk. p. 396–9.
12.
Chen P, Poddar R, Tipa EV, Dibello PM, Moravec CD, Robinson K, et al. Homocysteine metabolism in cardiovascular cells and tissues: Implications for hyperhomocysteinemia and cardiovascular disease. Vol. 39, Advances in Enzyme Regulation. p. 93–109.
13.
Eiken O, Mekjavic IB. The Valdoltra Bedrest Study: Effects of 35 days of horizontal bedrest on the function of peripheral blood vessels, the thermoregulatory system, and on the function and structure of the musculoskeletal system.
14.
Adams GR, Caiozzo VJ, Baldwin KM. Skeletal muscle unweighting: Spaceflight and ground-based models. Vol. 95, Journal of Applied Physiology. p. 2185–201.

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